Thymosin Beta-4 (5 Vials)
What is Thymosin Beta-4?
Thymosin Beta B, also known as TB4, consists of 43 amino acids. It can be found in all tissues and cell types, except for red blood cells. As with all peptides, it is something that we already have naturally occurring in the body. This amino acid is known for its regenerative abilities. TB4 levels rise significantly in areas where tissues have been damaged resulting in repair. Studies have shown that the use of TB4 can accelerate the healing process for soft tissue repair, dermal, and hair regeneration.
Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin beta-4, is an actin, a cell building protein.
One of the main mechanisms of action of Thymosin Beta-4 is its regulation of Actin. This cell-building protein is an essential component of cell structure and movement which leads to its role in tissue repair. Tβ 4 has been found to play an important role in protection, regeneration, and remodeling of injured or damaged tissues. After an injury, Tβ 4 is released by platelets and numerous other types of cells to protect the most damaged cells and tissues and to reduce inflammation and microbial growth.
How Thymosin Beta-4 Works
Recent studies have revealed that the first gene to be upregulated after an injury is a Tβ4 gene. As the body begins the recovery process, Tβ4 aids in the creation of new vessels in the injured area, which carry blood, nutrients, and reparative substances to the site. Tβ4 also has anti-inflammatory properties and works to decrease the amount of inflammatory substances, called cytokines. Inflammation plays a large role in many of the symptoms associated with a number of other conditions (i.e., Lyme disease, CFS, FM, autoimmune diseases, infections, etc.), making the potential impact of Tβ4 quite extensive.
The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following a heart attack due to its cardio and neuroprotective effects.
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| CAS: | 1627577591-33-4 | |
| MF: | C212H350N56O78S | |
| MW: | 4963 |
History of Thymosin Beta-4
Initial studies on TB-4 focused on its ability to promote wound healing and tissue repair. In animal studies, TB-4 was shown to accelerate wound healing, reduce inflammation, and promote tissue regeneration. These findings sparked interest in the potential therapeutic applications of TB-4 for a range of conditions, including skin injuries, muscle injuries, and cardiovascular disease.
Subsequent research has expanded on the potential benefits of TB-4, including its ability to promote angiogenesis (the formation of new blood vessels), reduce inflammation, and modulate the immune system. TB-4 has also been studied for its potential to protect the heart against damage from ischemia (lack of blood flow) and to enhance the regeneration of damaged heart tissue.
In recent years, TB-4 has also been investigated for its potential as a performance-enhancing drug. Some athletes and bodybuilders have used TB-4 to improve muscle recovery, increase endurance, and enhance overall athletic performance.
Despite the potential therapeutic benefits of TB-4, its use has been somewhat controversial due to concerns over its safety and potential side effects. Some studies have suggested that long-term use of TB-4 may increase the risk of cancer, although more research is needed to fully understand these risks.
Overall, the history of TB-4 is one of ongoing research and exploration into its potential therapeutic benefits. While more studies are needed to fully understand its effects and safety, TB-4 remains an area of active interest for researchers and clinicians alike.
More about Thymosin Beta-4
- Science Direct: https://www.sciencedirect.com/search?qs=thymosin+beta+4
Thymosin Beta-4 Research
- Zhang J, Zhang X, Tang H, Zhang Q, Hua S. Thymosin beta 4 promotes wound healing and modulates inflammatory cytokines in a full-thickness skin wound model in mice. Int J Clin Exp Med. 2015;8(6):8735-8741. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556639/
- Huang YC, Chen JH, Chou CT, et al. Thymosin beta-4 improves dermal burn wound healing via downregulation of the inflammatory response. Burns. 2014;40(3):500-510. https://www.sciencedirect.com/science/article/abs/pii/S0305417913004743
- Lee JH, Cho YS, Cho HJ, et al. Thymosin beta-4 promotes angiogenic activities in endothelial progenitor cells through activation of Akt signaling. Stem Cells Dev. 2012;21(15):2861-2870. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436882/
- Sosne G, Qiu P, Goldstein AL, Wheater M. Biological activities of thymosin beta 4 defined by active sites in short peptide sequences. FASEB J. 2010;24(6):2144-2151. https://journals.sagepub.com/doi/10.1177/1535370211400996
- Smart N, Risebro CA, Melville AA, et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445(7124):177-182. https://www.nature.com/articles/nature05383
- Yang M, Wang X, Zhang X, et al. Thymosin beta-4 induces proliferation and inhibits apoptosis of hepatocellular carcinoma cells through activation of the PI3K/Akt pathway. Oncotarget. 2016;7(14):18035-18047. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951333/
- Han Y, Hu L, Wu T, et al. Thymosin β4 protects cardiomyocytes from oxidative stress by targeting miR-128-3p. Antioxid Redox Signal. 2019;30(3):378-392. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333649/
- Huang YC, Chen JH, Wu YC, et al. Thymosin beta-4 attenuates early diabetic nephropathy by promoting autophagy and inhibiting apoptosis in podocytes. FASEB J. 2018;32(4):2165-2178. https://journals.sagepub.com/doi/full/10.1096/fj.201700556R
- Kim J, Kim M, Lee SJ, et al. Thymosin beta-4 enhances endothelial progenitor cell recruitment and neovascularization following hindlimb ischemia in mice. Cell Transplant. 2019;28(1):68-76. https://journals.sagepub.com/doi/10.1177/0963689718800827
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. https://www.tandfonline.com/doi/full/10.1517/
Buy <h4 class="nitro-offscreen">Thymosin Beta-4 <strong>– 5mg (5 Vials) </strong></h4> <h5><strong> $50.48 per vial</strong></h5> - $252.41 | Us Chem Labs | 99% Pure!
Buy Thymosin Beta-4 – 5mg (5 Vials) $50.48 per vial - $252.41. Us Chem Labs provides the highest quality, highest purity peptides at the lowest price per milligram.
Product SKU: thymosin-beta4-2mg-5-vials
Product Brand: US Chem Labs
Product Currency: USD
Product Price: 108.55
Price Valid Until: 2023-12-31
Product In-Stock: InStock
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