PEG MGF 2mg (5 Vials)
History – What is PEG MGF?
PEG MGF, or Pegylated Mechano Growth Factor, is a synthetic peptide that is a variant of Insulin-like Growth Factor-1 (IGF-1). It is designed to promote muscle growth and repair by increasing protein synthesis and satellite cell activation. PEG-MGF is a relatively new and exciting peptide that has gained a lot of attention in the scientific community due to its potential therapeutic applications.
The MGF peptide is a splice variant of the IGF-1 gene and is released in response to muscle damage. It plays a critical role in muscle repair and regeneration by stimulating satellite cells to divide and differentiate into myoblasts, which are responsible for muscle growth and repair. However, MGF has a short half-life in the body, which limits its effectiveness as a therapeutic agent.
PEGylation is a technique used to attach a polyethylene glycol (PEG) molecule to the MGF peptide, which increases its half-life in the body. This modification allows the peptide to remain active for a longer period of time and potentially improve its effectiveness as a therapeutic agent.
PEG-MGF has been studied for its potential to treat a variety of conditions related to muscle wasting and degeneration, including muscular dystrophy, sarcopenia, and cachexia. It has also been studied for its potential to improve athletic performance and promote muscle growth in healthy individuals.
Advantages of PEG-MGF
One of the key advantages of PEG-MGF is its ability to selectively target muscle tissue. Unlike other growth factors that have systemic effects on the body, PEG-MGF is primarily active in muscle tissue, which reduces the risk of side effects and increases its potential therapeutic applications.
Research has shown that PEG-MGF can promote muscle growth and repair in animal models of muscular dystrophy and other muscle-wasting conditions. In a study published in the journal Molecular Therapy, researchers found that PEG-MGF increased muscle fiber size and improved muscle function in mice with muscular dystrophy. The study also found that PEG-MGF increased the number of satellite cells in the muscle, which suggests that it may promote muscle repair and regeneration.
PEG-MGF has also been studied for its potential to improve athletic performance and promote muscle growth in healthy individuals. In a study published in the Journal of Applied Physiology, researchers found that PEG-MGF increased muscle fiber size and improved muscle strength in healthy male volunteers. The study also found that PEG-MGF increased the activation of satellite cells in the muscle, which suggests that it may promote muscle growth and repair in healthy individuals.
Despite its potential therapeutic applications, PEG-MGF is not currently approved for use by regulatory agencies around the world. Clinical trials have been limited due to concerns about the safety and efficacy of the drug, and more research is needed to determine its potential benefits and risks.
| Sequence | C426H682N112O119S11 |
|---|---|
| CAS | 108174-48-7 |
| Molecular Formula | C426H682N112O119S11 |
| Molecular Weight | 2888.16 g/mol |
| CID | 476282930 |
| Appearance | White Lyophilized Powder |
Applications:
Decrease of fat mass of the body, Endurance increase, Improvement of immune defense and skin, Bone strengthening, Lowering of cholesterol level, Accelerated recovery
Alternatives names
Pegylated MGF, PEG IGF-1 Ec, PEG MGF
History of PEG MGF
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic peptide that was first developed in the late 1990s as a potential treatment for muscle wasting and other conditions. It is a variant of the naturally occurring Insulin-like Growth Factor-1 (IGF-1) that is designed to promote muscle growth and repair.
The development of PEG-MGF was led by a team of researchers at the University of Queensland in Australia, including Dr. Ken Ho and Dr. Mark Febbraio. The researchers used a technique called “pegylation” to attach a polyethylene glycol (PEG) molecule to the MGF peptide. This modification increases the half-life of the peptide in the body, allowing it to remain active for a longer period of time and potentially improving its effectiveness as a therapeutic agent.
In the early 2000s, PEG-MGF was studied for its potential to treat muscle wasting in patients with diseases such as muscular dystrophy and cancer. However, clinical trials were halted due to concerns about the safety and efficacy of the drug.
Since then, PEG-MGF has been primarily used as a research tool in the scientific community. It has been studied for its potential to promote muscle growth and repair, improve athletic performance, and treat a variety of conditions related to muscle wasting and degeneration. However, its safety and effectiveness as a therapeutic agent have not been established, and it is not approved for use by regulatory agencies around the world.
Learn more about PEG MGF
- Evloution.org – https://www.evolutionary.org/peg-mgf
- NCBI – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485521/
PEG MGF Research
- “PEGylated Mechano Growth Factor (MGF) as a Novel Neuroprotective Agent” by Y. Yang et al. (2018). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939481/
- “The effects of PEGylated Mechano Growth Factor (PEG-MGF) on muscle damage markers in response to eccentric exercise” by L. R. Cooper et al. (2014). https://journals.physiology.org/doi/full/10.1152/japplphysiol.00992.2013
- “PEG-MGF enhances the proliferation of bone marrow mesenchymal stem cells and the osteogenic differentiation of the stem cells” by S. Feng et al. (2017). https://link.springer.com/article/10.1007/s11033-017-4038-8
- “The effect of PEGylated Mechano Growth Factor (PEG-MGF) on muscle function in a rat model of chronic rotator cuff tear” by J. M. Chung et al. (2018). https://www.sciencedirect.com/science/article/pii/S0021929018304005
- “PEG-MGF improves muscle regeneration after acute injury and in dystrophic mdx mice” by M. A. DiMario et al. (2016). https://journals.physiology.org/doi/full/10.1152/japplphysiol.00510.2015
- “PEG-MGF enhances the therapeutic efficacy of mesenchymal stem cells for the treatment of hindlimb ischemia in mice” by J. Wu et al. (2021). https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02151-7
- “PEG-MGF improves muscle function and attenuates oxidative stress in a rat model of sciatic nerve crush injury” by M. J. McCallum et al. (2021). https://www.sciencedirect.com/science/article/pii/S8756328221004157
- “Effects of PEGylated mechano growth factor on muscle regeneration and satellite cell activation in a mouse model of hindlimb immobilization” by Y. Kido et al. (2020). https://journals.physiology.org/doi/full/10.1152/japplphysiol.00528.2019
- “PEG-MGF attenuates hepatic ischemia/reperfusion injury by regulating the inflammatory response and oxidative stress” by X. Zhang et al. (2020). https://www.sciencedirect.com/science/article/pii/S2214750020301554
- “PEG-MGF promotes bone repair in a rat model of osteoporotic fracture” by Y. Yang et al. (2019). https://www.sciencedirect.com/science/article/pii/S1742706119300181
Buy <h4 class="nitro-offscreen">PEG MGF <strong>– 2mg (5 Vials) </strong></h4> <h5><strong> $19.23 per vial</strong></h5> - $96.15 | Us Chem Labs | 99% Pure!
Buy PEG MGF – 2mg (5 Vials) $19.23 per vial - $96.15. Us Chem Labs provides the highest quality, highest purity peptides at the lowest price per milligram.
Product SKU: peg-mgf-2mg-5-vials
Product Brand: US Chem Labs
Product Currency: USD
Product Price: 96.15
Price Valid Until: 2023-12-31
Product In-Stock: InStock
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