MOTs-C – 10mg (5 Vials)
History – What is the MOTS-c Peptide?
MOTS-c (human) acetate is a mitochondrial-derived peptide. MOTS-c (human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity[1].
The human body needs a certain amount of proteins in order to operate properly. When our bodies are depleted with these proteins, we need to consume food or supplements that contain amino acids to replenish the proteins that the system is lacking. Peptides are types of supplements that contain essential amino acids that the body can’t naturally produce itself. There are multiple peptides that can enhance certain bodily functions when the system can no longer do it. Peptide MOTS-c is derived from the mitochondria; the powerhouse of the cell, and it contains 16 amino acids to promote metabolic balance.
The Benefits of MOTS-c Peptide
Peptide MOTS-c has a wide-range of benefits for patients struggling with weight loss or athletes attempting to improve their athleticism. It can help individuals restore insulin sensitivity (which declines as people age or gain weight). Research done by the University of Southern California discovered that this peptide can assist in fighting weight gain, normalize metabolism, promote fatty acid metabolism within the liver, control mitochondrial energy, improve blood sugar control, prevent osteoporosis, and transform glucose into usable energy.
This is essential for those enduring obesity or type 2 diabetes. Additionally, the National Center for Biotechnology of Information (NCBI) suggests that there is a biological link between this peptide and the extended existence of the Japanese population (also known as the country with the longest lifespan in the world)².
This research further adds scientific data that MOTS-c has an influence over an individual’s longevity. MOTS c inhibits the folate cycle at the level of 5Me-THF, resulting in an accumulation of AICAR [5-aminoimidazole-4-carboxamide ribonucleotide). MOTS c also increases cellular NAD+ levels, which are also nucleotide precursors[1].
MOTS-c is a mitochondrial signal that stimulates cellular glucose uptake while suppressing respiration. The glucose taken up in response to MOTS-c is routed to the anabolic pentose phosphate pathway (PPP), which provides carbon sources for the synthesis of purines, rather than being metabolized through glycolysis. In addition, MOTS c increases the levels of carnitine shuttles, which transport activated fatty acids into the mitochon-dria for β-oxidation, increases the level of a β-oxidation intermediate, and reduces intracellular levels of essential and non-essential fatty acids, suggesting enhanced lipid utilization; myocytes that stably overexpress MOTS c also exhibits increased glucose uptake.
| Sequence | C101H152N28O22S2 |
|---|---|
| CAS | 1627580-64-6 |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.62 g/mol |
| CID | 146675088 |
| Appearance | White Lyophilized Powder |
MOTS-c injections in mice show activation of skeletal muscle AMPK and increased the level of its downstream glucose transporter GLUT4. MOTS-c may also act as a potential mitochondrial signal that mediates an exercise-induced mitohormesis response, thereby stimulating physiological adaptation and increased tolerance to exercise.
The primary target organ of MOTS-c appears to be skeletal muscle and fat. MOTS-c levels in mice decline with age in skeletal muscle and in circulation concomitantly with the age-dependent development of insulin resistance. Restoring MOTS-c levels by systemic injections in older mice (12 mo.) successfully reverses age-dependent skeletal muscle insulin resistance.
About MOTs-C
Research has suggested MOTS c is an exercise mimetic, a 16-amino-acid peptide that is encoded in the mitochondrial genome of cells. According to clinical studies, it improves insulin sensitivity. While the study is still ongoing, control group examinations using diet-induced obese mice have shown improvements in insulin sensitivity. Researchers are still studying to see if the MOTS c changes plasma markers, which are used to determine the body’s metabolic condition.
Research has shown that it targets body muscles and regulates its metabolism using the folate-purine-AMPK pathway. By doing so, it becomes effective protection against obesity and insulin resistance that stems from the diet that one is taking or age.
How Mots-C Peptide Regulates Glucose
Clinical studies have shown that MOTS c promotes the production of endogen AMP analogue AICAR, which in turn, helps in the synthesis of AMP-activated protein kinase (also referred to as AMPK). Before the production of AMPK, its cellular actions inhibit the folate cycle along with de novo purine biosynthesis. The AMPK then induces systemic cellular uptake of glucose and enhances insulin sensitivity. These studies suggest the mitochondria offer active regulation of metabolic homeostasis via this peptide encoded in their genome.
Research has confirmed that the peptide genome can help reduce insulin resistance. Health experts recommend taking the medication along with a strict, balanced diet to lower the amount of fat taken to manage obesity. Other studies have shown that general weight gain may increase insulin insensitivity, especially on diabetes type 1 patients. Cutting down the fat intake and increased levels of MOTSc may lower the diet-induced metabolic dysfunction and associated inflammation.
History Of MOTs-c
MOTs-c, also known as mitochondria-derived peptides or humanin-like peptides, are a group of small peptides that are derived from the mitochondrial genome. The discovery of these peptides is a relatively recent development in the field of mitochondrial biology, and their potential therapeutic applications are still being explored.
The first mitochondrial-derived peptide to be discovered was humanin, which was identified in 2001 by a team of researchers led by Dr. Pinchas Cohen at the University of California, Los Angeles. Humanin was found to have neuroprotective properties, and it was subsequently studied for its potential as a treatment for Alzheimer’s disease and other neurodegenerative conditions.
In 2013, Dr. Cohen and his colleagues discovered another mitochondrial-derived peptide, called MOTS-c (mitochondrial open reading frame of the 12S rRNA-c). MOTS c was found to have metabolic effects, and it was shown to improve insulin sensitivity and glucose metabolism in animal models. Since its discovery, MOTS c has been studied for its potential therapeutic applications in diabetes, obesity, and other metabolic disorders.
Research on MOTS-c and other mitochondrial-derived peptides is ongoing, and their precise mechanisms of action and potential clinical uses are still being explored. However, the discovery of these peptides has opened up new avenues for research into the role of mitochondria in human health and disease, and they may represent a promising area of study for the development of new treatments for a variety of conditions.
More MOTs C Information
- Onlinelibracy.com: https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14171
- Cell.com: https://www.cell.com/article/s1550-4131(15)00061-3/abs
- NCBI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801219/
MOTs C Research
- “Mitochondrial derived peptides as potential targets of therapies for metabolic disorders” by Dong-Mei Zhang et al. (2021) – https://www.sciencedirect.com/science/article/pii/S009829972100009X
- “Mitochondria-derived peptides and type 2 diabetes: a review of potential applications” by Shiqian Dong et al. (2021) – https://www.sciencedirect.com/science/article/pii/S2095254620303761
- “MOTS-c and its potential applications in metabolic diseases” by Lei Song et al. (2019) – https://www.sciencedirect.com/science/article/pii/S2095254618307574
- “Mitochondrial-derived peptides: novel regulators of metabolism” by Jie Zhu et al. (2019) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355645/
- “MOTS-c: A Review of Its Potential Role in Metabolic Diseases” by Aijuan Qu et al. (2018) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316092/
- “MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism” by Pei Wang et al. (2018) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271513/
- “Mitochondrial-derived peptides in energy metabolism” by Alena O. Zakharova et al. (2018) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960121/
- “Mitochondria-derived peptides as metabolic regulators” by Chunyan Wu et al. (2018) – https://www.sciencedirect.com/science/article/pii/S1567724917305762
- “Mitochondrial-derived peptides in health and disease” by Ning Zhang et al. (2018) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945812/
- “Mitochondrial-derived peptides in aging and age-related diseases” by Hongyun Li et al. (2018) – https://www.sciencedirect.com/science/article/pii/S2213231717306279
- “Mitochondrial-derived peptides as potential therapies for metabolic dysfunction” by Peter M. Coop et al. (2017) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716842/
- “Mitochondrial-derived peptides in cardiovascular disease: focus on novel mechanisms and approaches for therapy” by Chantal M. Boulanger et al. (2017) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671019/
- “Mitochondrial-derived peptides: a new mitochondrial communication pathway between the endoplasmic reticulum and the mitochondria” by José Manuel Villalba et al. (2016) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323244/
- “Mitochondrial-derived peptides as regulators of metabolism” by Miao Liu et al. (2016) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975772/
- “Mitochondria-derived peptides in cancer metabolism” by Shuyu Zhang et al. (2016) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987389/
- “Mitochondrial-derived peptides in metabolic regulation” by P. Hemachandra Reddy et al. (2016) – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839537/
Buy MOTs-C 10mg online $38.32 per vial - 5 vials $191.60 | 99% Pure! | Us Chem Labs
Buy MOTs-C 10mg online $38.32 per vial - 5 vials $191.60. Us Chem Labs provides the highest quality, highest purity peptides at the lowest price per milligram.
Product SKU: mots-c-10mg-5-vials
Product Brand: US Chem Labs
Product Currency: USD
Product Price: 191.6
Price Valid Until: 2023-12-31
Product In-Stock: InStock
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